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Chemdex.com was one of the first online business-to-business (B2B) e-commerce companies. Based in the United States, Chemdex provided an online marketplace for sales of chemicals, enzymes, lab equipment, biotech products like peptides, and many types of chemical reagents. Once an IPO darling of Wall Street, it was never profitable and it became one of many companies destroyed in the dot-com crash of the early 2000s.
Chemdex was started in 1997 by former Exxon engineer David Perry in Palo Alto, California, and received venture capital from Genentech founder Robert A. Swanson, and from VC firms Kleiner Perkins Caufield & Byers and CMGI@Ventures.
Chemdex's flotation on the NASDAQ exchange in July 1999 (ticker symbol CMDX) was typical of other initial public offerings of "dot-com" companies during the dot-com bubble. At the time Chemdex recorded quarterly sales of $165,000, mostly to Genentech, and had lost $6.8 million in the same quarter. Yet it raised $112.5 million at IPO, and its stock rose 60% on the first day, valuing the whole company (including those shares still privately held) at over $750 million). 
Chemdex spawned its own parent, Ventro Corporation. Ventro merged with a number of related businesses, including Specialty MD and Promedix (both specialty medical technology providers) and engaged in joint ventures with Tenet Healthcare and VWR Scientific. By 2000 the company's market capitalization had grown to over $4 billion. 
When, as with other similar companies, investors lost confidence in highly-priced but unprofitable internet ventures, Ventro's stock plummeted to only 1% of its previous value, and (unable to find a buyer for the business) Ventro shut its Chemdex division down in early 2001.  Instead Ventro concentrated on only providing B2B exchange services to exchanges rather than actually running an exchange. Ventro eventually merged with Nexprise.
- ↑ "Chemdex shines on market debut news.com July 28, 1999, URL retrieved 18 June 2006
- ↑ "The Days and Nights of David Perry", In Vivo: The Business & Medicine Report February 2000, URL retrievd 18 June 2006
- ↑ "The Fall of Chemdex" About.com, URL retrieved 18 June 2006
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